Life has dealt casino card dealer Luke Vaughn (Jeffrey Dean Morgan) a lousy hand. He has until Friday to find $300,000 to pay for a surgery to save his young daughter’s life. Having exhausted his money and options, with time ticking away, Vaughn decides to ask his longtime boss, Frank Pope (Robert De Niro) for a loan.
Pope refuses and Vaughn turns to a new co-worker cashier Jason Cox, (Dave Bautista) who has figured out the logistics of Pope’s laundering operation, and agrees to help him steal the money.
Although Vaughn, Cox, and an accomplice, Dante (Stephen Sepher), carefully plan out each minute of the late-night heist, Cox blows the timing, setting off alarms and a shootout with Dog and casino security. When they escape with $3 million in laundered cash only to find their getaway car is gone, the trio runs through the night and boards Bus 657.